At Higher Risk • People older than 60, especially those with a history of bowel disease. • People with changes in the small intestine acidity, rapid transit and nitrosamine exposure. • Those with inherited gastrointestinal disorders—Peutz-Jeghers syndrome, familial polyposis , inflammatory bowel disease, Crohn's disease and neurofibromatosis. • Those with increased lymphoid deposits in the ileum and immune deficiency diseases are at a higher risk for lymphomas. • A history of or the presence of a Helicobacter pylori infection may lead to small bowel inflammation that may lead to the initiation of a lymphoma.